A SHORT REVIEW ON PYRAZOLE DERIVATIVES & THEIR APPLICATIONS
Keywords:
pyrazole, synthesis methods, dehydrogenating 2-pyrazolineAbstract
Pyrazole is a 2-neighbour nitrogen containing 5-membered heterocyclic organic compound with three carbon atoms. Pyrazole commonly known as 1,2 diazoles has been very popular now a days due to manifold uses. There are number of pyrazole derivative which has broad spectrum of biological activities like anti-bacterial, anti-microbial, anti-inflammatory, anti-convulsant, analgesic, anti-diabetic, anti-rheumatic, anti-cancer, and anti- tuberculosis. There are several applications of pyrazole core based organic molecules in various areas including pharmacy and agro-chemical industries. The purpose of the review was to collect various pharmacological actions which were reported in recent years made on its moiety. Pyrazole and its derivatives are prepared by dehydrogenating 2-pyrazoline or its derivative by process in which the reaction is carried out using sulfuric acid in the presence of iodine or of an iodine compound. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Development of pyrazole and its derivative has been reported by many scientists in decades.
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