Blood Brain Barrier and Hepatic Encephalopathy
Keywords:
Blood Brain, EncephalopathyAbstract
Dyshomeostasis of the central nervous system (CNS) is a critical factor in HE physiology, homeostasis of nerve cells are maintained in a very limited range where in ions concentration such as Na+, K+, Ca+ along with different metabolites for proper neuronal functioning (Rolfe and Brown, 1997). CNS necessitates highly regulated extracellular environment, as is a critical and sensitive system in human body. The homeostasis is maintained by blood-brain barrier (BBB). A complex system of brain microvascular endothelial cells with connection made by a junctional complex with adherens and tight junction. The brain cells are characterised with slightest pinocytic ability, no fenestrations while great number of ATP-binding cassette (ABC) transporter. Brain stays in an extremely regulated environment with about 20% of blood supply of body. But, unlike all other organs of body, no direct exchange of molecules or cells occur between blood and brain.
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