Multi-component one pot assisted synthesis, anti-bacterial capabilities and scanning electron microscopy of novel corticosteroid thiopyran

Yogita Sharma

doi:10.36676/irt.v10.i1.1425

Authors

Yogita Sharma Extension lecturer in chemistry

DOI:

https://doi.org/10.36676/irt.v10.i1.1425

Keywords:

diseases, biological, steroid, corticosteroids, hormones

Abstract

Corticosteroids as an influential class of multi-cyclic molecules particularly performing pivotal roles in governing regular physiological processes as well as spotting the biological sites which are related to diseases. There is manifest that a statistic of biologically most important steroids are modified forthwith in clinic for the succour of diseases. Ring system1 as well as side chain2 chemical modification of the steroid impart procedures of the functional groups alteration3. These compounds could be used for performing physiological measures and addressing biologically disease-related sites4–8 particularly steroid hormones such as corticosteroids that are amalgamated and exonerate in the adrenal gland play an indispensable portrayal in governing stress.

References

R. Singh and G. Panda, Tetrahedron, 2013, 69, 2853–2884.

D. Kakati, R. K. Sarma, R. Saikia, N. C. Barua and J. C. Sarma, Steroids, 2013, 78, 321–6.

N. T. Shahidi, Clin. Ther., 2001, 23, 1355–90.

D. E. Becker, Anesth. Prog., 2013, 60, 25–31; quiz 32.

L.-H. Huang, Y.-F. Zheng, Y.-Z. Lu, C.-J. Song, Y.-G. Wang, B. Yu and H.- M. Liu, Steroids, 2012, 77, 710–5.

B.-L. Zhang, E. Zhang, L.-P. Pang, L.-X. Song, Y.-F. Li, B. Yu and H.-M. Liu, Steroids, 2013, 78, 1200–8.

D. Poirier, J. Steroid Biochem. Mol. Biol., 2013, 137, 174–5.

A. Gupta, B. S. Kumar and A. S. Negi, J. Steroid Biochem. Mol. Biol., 2013,

137, 242–70.

G. Briassoulis, S. Damjanovic, P. Xekouki, H. Lefebvre and C. A. Stratakis,

Endocr. Pract., 2011, 17, 941–8.

N. C. Nicolaides and E. Charmandari, Hormones (Athens)., 2017, 16, 124– 138.

C. A. Stratakis, M. Karl, H. M. Schulte and G. P. Chrousos, Ann. N. Y. Acad. Sci., 1994, 746, 362–74; discussion 374-6.

F. Buttgereit, Clin. Exp. Rheumatol., 2003, 21, 145–7.

F. Buttgereit, J. W. J. Bijlsma and C. Strehl, Clin. Immunol., 2018, 186, 64– 66.

H. Schäcke, W. D. Döcke and K. Asadullah, Pharmacol. Ther., 2002, 96, 23– 43.

A. E. Amr, M. M. Abdalla, M. M. M. Hussein, H. M. Safwat and M. H. Elgamal, Russ. J. Gen. Chem., 2017, 87, 305–310.

B. Yu, Z. Cai, S. Wang and H. Liu, Chinese J. Org. Chem., 2017, 37, 1952.

Y. A. Maklad and M. M. Nosseir, Sci. Pharm., 2000, 68, 141–157.

Y.-L. Zhang, Y.-F. Li, X.-L. Shi, B. Yu, Y.-K. Shi and H.-M. Liu, Steroids, 2016, 115, 147–153.

F. Tavakolinia, T. Baghipour, Z. Hossaini, D. Zareyee, M. A. Khalilzadeh and

M. Rajabi, Nucleic Acid Ther., 2012, 22, 265–70. 20. S. W. Schneller, 1975, 59–97.

E. Vedejs and G. A. Krafft, Tetrahedron, 1982, 38, 2857–2881.

M. J. Brown, P. S. Carter, A. S. Fenwick, A. P. Fosberry, D. W. Hamprecht,

M. J. Hibbs, R. L. Jarvest, L. Mensah, P. H. Milner, P. J. O’Hanlon, A. J. Pope, C. M. Richardson, A. West and D. R. Witty, Bioorg. Med. Chem. Lett., 2002, 12, 3171–4.

W. Quaglia, M. Pigini, A. Piergentili, M. Giannella, F. Gentili, G. Marucci, A. Carrieri, A. Carotti, E. Poggesi, A. Leonardi and C. Melchiorre, J. Med. Chem., 2002, 45, 1633–43.

L. A. van Vliet, N. Rodenhuis, D. Dijkstra, H. Wikström, T. A. Pugsley, K. A. Serpa, L. T. Meltzer, T. G. Heffner, L. D. Wise, M. E. Lajiness, R. M. Huff,

K. Svensson, S. Sundell and M. Lundmark, J. Med. Chem., 2000, 43, 2871– 82.

W. Wang, H. Li, J. Wang and L. Zu, J. Am. Chem. Soc., 2006, 128, 10354–5.

Y. Sugita, H. Hosoya, K. Terasawa, I. Yokoe, S. Fujisawa and H. Sakagami,

Anticancer Res., 2001, 21, 2629–32.

J. J. Hollick, B. T. Golding, I. R. Hardcastle, N. Martin, C. Richardson, L. J.

M. Rigoreau, G. C. M. Smith and R. J. Griffin, Bioorg. Med. Chem. Lett., 2003, 13, 3083–6.

I. Ahmad and A. Z. Beg, J. Ethnopharmacol., 2001, 74, 113–23.

Y. Wen, W. Huang, B. Wang, J. Fan, Z. Gao and L. Yin, Mater. Sci. Eng. B, 2012, 177, 619–624.

S. Shrivastava, T. Bera, A. Roy, G. Singh, P. Ramachandrarao and D. Dash,

Nanotechnology, 2007, 18, 225103.